Pardee, K. et. al., Cell (2016), http://dx.doi.org/10.1016/j.cell.2016.04.059, http://www.ncbi.nlm.nih.gov/pubmed/27160350
Zika has proven challenging due to its close relation to other viruses such as Dengue. Pardee et al have developed a low cost field test that couples isothermal RNA amplification with toehold switch RNA sensors to detect Zika. The assay provides a quick readout using a colorimetric change of the sensor. By adding in a CRISPR/Cas9 component the researchers were able to provide an assay that can even distinguish between strains of Zika with single-base resolution. Development of these types of tools should help researchers efficiently determine how quickly the Zika virus is spreading.