US Scientists Correct Dominant Mutation in Human Embryos

Pam Belluck, 2 August 2017, New York Times https://www.nytimes.com/2017/08/02/science/gene-editing-human-embryos.html

In a newly published Nature article (https://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html), a multinational group of researchers from the United States, South Korea, and China successfully corrected the autosomal dominant mutation HCM, responsible for myocardial disease.  In contrast to previous attempts, this study co-injected the CRISPR/Cas machinery with the sperm which resulted in non-mosaic embryos that could be safely implanted.  Further demonstrating the advances made in this study, full genome sequencing revealed no off-target edits.  While this report demonstrates the potential genome editing has to eliminate genetic disease, more research is required to ensure efficacy along with public discussions over the ethical implications.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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