Ed Yong, The Atlantic, 13 December 2017 https://www.theatlantic.com/science/archive/2017/12/turning-piglets-into-personalized-avatars-for-sick-kids/548204/
Certain diseases have been woefully understudied by the scientific community for a variety of reasons. Neurofibromatosis type 1 or NF-1, is one such disease that results from mutations in the Neurofibromatosis-1 gene. Since many different mutations causes the disease, each with their own symptoms, it has been challenging to develop models to study treatment options. CRISPR could potentially be used to create swine models with the exact mutation of an affected individual allowing for treatments to be screened for their efficacy prior to use in humans.