Eric S. Lander, Cell (2016) 164:18-28 http://www.ncbi.nlm.nih.gov/pubmed/26771483
Major scientific discoveries rarely, if ever, occur in a single lab at a single moment in time. Instead they involve many people, institutions, and years. The discovery of CRISPR is no different with story spanning two decades. This review by Eric Lander focuses on the main players that worked toward understanding the CRISPR loci while making an argument for funding basic science and the promotion of “hypothesis-free” research based on big data.