Sontheimer E.J and Davidson, A.R. (2017) Current Opinions in Microbiology. 37:120-127. https://www.ncbi.nlm.nih.gov/pubmed/28668720
As with every immune system, invading organisms have developed ways to bypass an organism’s defenses. The CRISPR/Cas system is no different with viruses developing anti-CRISPR proteins. This review surveys anti-CRISPR proteins and how they could be used to enhance CRISPR gene editing.