Scientists successfully edit chicken germ lines using CRISPR/Cas9

Dimitrov, L., et. al. Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells. (2016) PLoS ONE 11(4): e0154303. doi:10.1371/journal.pone.0154303. http://www.ncbi.nlm.nih.gov/pubmed/27099923

Genetic modification of birds has proven challenging due limited access to fertilized zygotes.  German researchers used CRISPR/Cas9 to overcome this barrier.  Primordial germ cells were modified in vitro and subsequently introduced to the germ line.  The resulting offspring were modified at the targeted IgH gene demonstrating that editing chicken genomes is possible with CRISPR/Cas9.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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