Jackson, R.N. et. al. (2017) Current Opinions in Microbiology. 37:110-119. https://www.ncbi.nlm.nih.gov/pubmed/28646675
The CRISPR adaptive immune systems in bacteria and archaea are regulated through a series of checkpoints that prevent the self-targeting of the hosts genetic material. Understanding the mechanisms of CRISPR regulation may allow for fewer off-target effects during CRISPR gene editing. This review covers our current understanding of CRISPR regulation and identifies conserved themes.