Regulation of CRISPR-Associated Nucleases

Jackson, R.N. et. al. (2017) Current Opinions in Microbiology. 37:110-119. https://www.ncbi.nlm.nih.gov/pubmed/28646675

The CRISPR adaptive immune systems in bacteria and archaea are regulated through a series of checkpoints that prevent the self-targeting of the hosts genetic material.  Understanding the mechanisms of CRISPR regulation may allow for fewer off-target effects during CRISPR gene editing.  This review covers our current understanding of CRISPR regulation and identifies conserved themes.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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