Overbeek, M., et. al. (2016) Molecular Cell 63:633-646 http://www.ncbi.nlm.nih.gov/pubmed/27499295
NHEJ repairs have been considered a random process. However, a recent report indicates that NHEJ may be a non-random process. The identification of the repair seems to be influenced by the PAM sequence and not the surrounding gDNA in human HEK293 and HCT116 cell lines with the repair being completed by either the classical NHEJ pathway or the microhomology mediated end-joining pathway.