PHYS.org, November 18, 2015. http://phys.org/news/2015-11-technology-vastly-crisprcas9-accuracy.html
In an effort to improve CRISPR/Cas9 targeting research at the University of Massachusetts Medical School combined the old with the new. Zinc Finger DNA editing was originally developed in the early 1990’s by combining the DNA binding Zinc Finger protein domain with the Fok1 nuclease domain. Since then researchers have developed tools to design zinc-finger binding domains to target specific DNA sequences. The researchers at the University of Massachusetts combined this ability with the new CRISPR/Cas9 system by fusing a Zinc Finger domain to Cas9 to enhance the specificity of DNA targeting. By combining these two different DNA targeting technologies the risks of off target effects.