New CRISPR/Cas system discovered in archaea

Kerry Grens, The Scientist, 22 December 2016 http://www.the-scientist.com/?articles.view/articleNo/47845/title/New-CRISPR-Cas-Enzymes-Discovered/

In a new Nature (https://www.ncbi.nlm.nih.gov/pubmed/28005056) letter Burstein et. al. report the discovery of the first Cas9 identified in archaea and two small Cas enzymes from bacteria.  The new enzymes were discovered through a metagenomics approach by collecting samples from various field sites, extracting the DNA, and reconstructing the genomes which has resulted in a terabase-scale collection of genomic information.  Once putative genes were identified each Cas analog was expressed in E. coli to confirm its ability to block genetic information introduced into the cell.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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