Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

Bondy-Denomy, J. et al.  Nature (2015) 526:136-139. http://www.ncbi.nlm.nih.gov/pubmed/26416740

The CRISPR/Cas gene editing system is based upon an adaptive bacterial immune system against bacteriophages.  To overcome this immune system, phages have evolved proteins that inhibit CRISPR/Cas systems.  The mode of inhibition varies by type of Cas system targeted, but usually involves inhibiting the formation of the DNA-Cas complex.  Anti-Cas proteins might find use in gene editing techniques by modulating the activity of the Cas complex.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

Leave a Reply