Modeling large structural variations in iPSCs with CRISPR/Cas9

Park, C. Y. et. al. (2016) Nature Protocols 11:2154-2169

While CRISPR/Cas9 gene editing has become an indispensable tool to model genetic disease, it has been limited to the creation and correction of simple mutations.   Presented here is a method developed by Park et. al. for the creation/correction of large chromosomal rearrangements in human induced pluripotent stem cells using CRISPR/Cas9 in approximately 2 weeks.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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