Park, C. Y. et. al. (2016) Nature Protocols 11:2154-2169 https://www.ncbi.nlm.nih.gov/pubmed/27711053
While CRISPR/Cas9 gene editing has become an indispensable tool to model genetic disease, it has been limited to the creation and correction of simple mutations. Presented here is a method developed by Park et. al. for the creation/correction of large chromosomal rearrangements in human induced pluripotent stem cells using CRISPR/Cas9 in approximately 2 weeks.