Mimivirus may not contain a CRISPR-like adaptive immunity system

Tanya Lews, 7 July 2016, The Scientist, http://www.the-scientist.com/?articles.view/articleNo/46493/title/Researchers-Cast-Doubt-on-CRISPR-Like-System-in-Giant-Viruses/

In April of 2015 Levasseur et al. published a Nature Letter claiming that the giant mimivirus contained an adaptive immune system similar to that of the bacterial CRISPR/Cas9 system.  However in a recent perspective published in Virologica Sinica (http://link.springer.com/article/10.1007%2Fs12250-016-3801-x) Claverie and Abergel state that “MIMIVIRE is not analogous to the CRISPR-Cas system, does not function via a nucleic acid recognition system, and is unlikely to possess all the attributes of a bona fide adaptive immune system.”  The authors of the original paper dispute this claim stating that the comparison “is an analogy, not a homology.”

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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