Maddalo et al. Nature (2014) 516:423-427. http://www.ncbi.nlm.nih.gov/pubmed/25337876
Many human cancers are the result of chromosomal rearrangements which has made modeling certain cancers in mice challenging. Using CRISPR/Cas9 gene editing Maddalo et al. were able to induce chromosomal rearrangements similar to those found non-small cell lung cancers in mouse lung tissue. CRISPR/Cas9 modified mice developed lung tumors when compared to control mice demonstrating the capability of CRISPR/Cas9 technology to selectively edit mouse tissues to study human cancers.