Niu et al. Cell (2014) 156:836-843. http://www.ncbi.nlm.nih.gov/pubmed/24486104
Monkeys are an important model for studying human disease and developing drug therapies. However their use has been limited by the inability to produce specific genetic modifications. By using the CRISPR/Cas9 system Niu et al. were able selectively disrupt both PPAR-γ and RAG1 in the cynomolgus monkey (Macaca fascicularis) with no off-target modifications detected, thus demonstrating that CRISPR/Cas9 technology could be used to further expand our knowledge of human disease through the use of monkey models.