Pulecio, J. et. al. (2017) Cell Stem Cell 21:431-447. https://www.ncbi.nlm.nih.gov/pubmed/28985525
The CRISPR/Cas system has been quickly adopted as a genome editing tool, however recent advances are translating the system to the epigenome. This protocol review surveys the potential that CRISPR/Cas has to aid research into the impact of chromatin features have on gene expression and cell behavior.