Burkard, C., et. al. PLOS Pathogens, 23 Feb 2017. https://www.ncbi.nlm.nih.gov/pubmed/28231264
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) affects the pig industry worldwide by causing late-term abortions and stillbirths as well as respiratory disease in piglets. The virus enters the swine cells by binding to the SRCR5 region of CD163. By using CRISPR/Cas9 technology to knockout the CD163 receptor in pig zygotes, researchers engineered a line of pigs resistant to the PRRSV. The resistant pigs showed no adverse effects when maintained under standard industry conditions.