Engineering Resistance to Porcine Reproductive and Respiratory Syndrome

Burkard, C., et. al. PLOS Pathogens, 23 Feb 2017.

The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) affects the pig industry worldwide by causing late-term abortions and stillbirths as well as respiratory disease in piglets.  The virus enters the swine cells by binding to the SRCR5 region of CD163.  By using CRISPR/Cas9 technology to knockout the CD163 receptor in pig zygotes, researchers engineered a line of pigs resistant to the PRRSV. The resistant pigs showed no adverse effects when maintained under standard industry conditions.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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