Hockemeyer D., et. al. (2016) Cell Stem Cell. 5:573-586. https://www.ncbi.nlm.nih.gov/pubmed/27152442
The use of human induced pluripotent stem cells(hiPSCs) has allowed researchers to study a variety of diseases and gene functions in non-cancerous cell lines. However the ability to alter the genetics of these cells has posed a significant challenge. With the advent of CRISPR/Cas9 gene editing, modification of hiPSCs has become almost routine. The combination of these two technologies has changed how researchers study human genetics in a way that will fundamentally alter how scientists approach biomedical research.