CRISPR Used to Create First Ever Mutant Ants

Friedman, et. al. (2017) Cell 170:601-602. https://www.ncbi.nlm.nih.gov/pubmed/28802035

The social behavior of ants, and its genetic underpinnings, have long been of interest to researchers. However, study of ant genetics has been limited by the inability to create mutants.  With the publication of two independent reports in Cell (https://www.ncbi.nlm.nih.gov/pubmed/28802042, https://www.ncbi.nlm.nih.gov/pubmed/28802043), this limitation has been overcome thanks to CRISPR gene editing.  Both studies made the modifications by injecting freshly laid eggs with Cas9/sgRNA RNP complexes, followed by conversion of the edited ants into fertile female gamergates allowing for passage of edited alleles.  This technique could allow ants to become model organisms for the study of colonial animals.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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