CRISPR Off-Target Affects May be Greater than Previously Assumed

EurekAlert, Columbia University Medical Center Press Release, 29 May 2017, https://www.eurekalert.org/pub_releases/2017-05/cumc-cge052617.php

Since its discovery, the CRISPR/Cas9 system has been on an unprecedented pace towards clinical use, though a new Nature Letter may slow down this process.  In the letter, Unexpected mutations after CRISPR-Cas9 editing in vivo (https://www.ncbi.nlm.nih.gov/pubmed/28557981), researchers completed whole genome sequencing of CRISPR edited mice and discovered 1,500 single nucleotide mutations and greater than 100 larger deletions and insertions with none of the off-target mutations predicted by computer algorithms.  While this study could change the way CRISPR therapies progress, further researcher is needed to confirm the results.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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