CRISPR increases the speed of gene discovery

Sharon Begley, STAT News, 25 October 2016, https://www.statnews.com/2016/10/25/crispr-identifies-hiv-genes/

Scientists have known that mutations in certain genes, such as CCR5, impart resistance to HIV/AIDS, however the number of known HIV related genes has been low due to screening limitations.  With CRISPR/Cas9, scientists reduce the time required to screen large number of genes from years to months.  A recent publication in Cell Reports used CRISPR/Cas9 to mutate 45 genes, in both individuals and in combinations, to identify additional genes related to HIV infection, ultimately identifying 6 candidates.  While it is not yet known if these newly identified genes are suitable for clinical targeting, the ability to perform massive genetic screens could allow for additional HIV/AIDS treatments.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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