CRISPR gene drives could be used to modify sex ratios of mosquitos

Galizi, R., et. al. Scientific Reports (2016) 6:31139

Historically, mosquito populations have been managed in one of two ways, habitat elimination and the application of pesticides.  Recently gene drives have been proposed as a way to eliminate vector borne diseases such as malaria and zika.  These gene drives would use the CRISPR/Cas system to either reduce mosquito populations through sterilization or provide resistance to the pathogen.  Galizi et al. have proposed a new mechanism for gene drive based mosquito elimination by using the CRISPR/Cas system to “shred” the X-chromosome during male meiosis thereby producing a bias towards male offspring in the next generation.  This male bias would decrease the number of breeding females, ultimately resulting in a population crash.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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