Galizi, R., et. al. Scientific Reports (2016) 6:31139 http://www.ncbi.nlm.nih.gov/pubmed/27484623
Historically, mosquito populations have been managed in one of two ways, habitat elimination and the application of pesticides. Recently gene drives have been proposed as a way to eliminate vector borne diseases such as malaria and zika. These gene drives would use the CRISPR/Cas system to either reduce mosquito populations through sterilization or provide resistance to the pathogen. Galizi et al. have proposed a new mechanism for gene drive based mosquito elimination by using the CRISPR/Cas system to “shred” the X-chromosome during male meiosis thereby producing a bias towards male offspring in the next generation. This male bias would decrease the number of breeding females, ultimately resulting in a population crash.