CRISPR editing used to determine the mechanism for genome duplication in plants

Schiml et al, PNAS (2016) 113:7266-7271 http://www.ncbi.nlm.nih.gov/pubmed/27307441

Duplication of genome sequences is one of the main evolutionary drivers in plants, however the mechanism behind these duplications is not well understood.  By using Cas9 modified to only nick one strand of the DNA Schiml et al where able to induce genome duplications by nicking locations 25 bp-100 bp in length, providing a possible mechanism for genome duplication events.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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