CRISPR-edited pancreatic cells show reversal of Type 2 Diabetes symptoms

Lund University, Press Release, 1 December 2016, https://www.eurekalert.org/pub_releases/2016-12/lu-cei120116.php

Researchers at Lund University in Sweden used CRISPR to knockout an enzyme that contributed to the regulation of the diabetes-associated TXNIP gene, resulting in decreased cell death and increased insulin production.  Pancreatic cells were donated from both healthy and type 2 diabetes patients. The researchers first identified that the gene activity of HAT enzymes was higher in the diabetic cells compared to the healthy cells.  After using CRISPR/Cas9 to knock out the HAT enzyme from rats, they discovered that HAT knockout reduced TXNIP activity resulting in reduced cell death and increased insulin production.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

Leave a Reply