Klann TS, et. al. (2018) Current Opinion in Biotechnology. 52:32-41. https://www.ncbi.nlm.nih.gov/pubmed/29500989
High-throughput screens for coding regions of the genome have long relied on RNAi technology, but techniques for screening the non-coding regions have not existed until recently. This review covers how CRISPR technology can be harnessed for annotation of the non-coding regions through genomic and epigenomic screens.