Could the Immune System Prevent CRISPR Therapies?

Heidi Ledford, Nature, 08 Jan 2018, https://www.nature.com/articles/d41586-018-00335-8

According to research published on the preprint server BioRxiv, 79% of studied blood samples contained antibodies for Staphylococcus aureus Cas9 and 65% of samples contained antibodies for Streptococcus pyogenes Cas9.  Additionally, 46% of the 13 adult participates contained T cells targeting S. aureus Cas9.  While these data have not been peer-reviewed, it demonstrates potential challenges faced by in vivo editing with Cas9.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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