Could Casposons Have Given Rise to CRISPR?

Krupovic, M. et. al. (2017) Current Opinion in Microbiology 38:36-43.

Casposons are a superfamily of self-synthesizing transposons found in prokaryotes.  One identified casposon is homologous to the Cas1 endonuclease and could have evolved into the adaption module of the CRISPR/Cas system and the CRISPR repeats.  This opinion publication covers how the casposon system is similar and different from that of CRISPR/Cas and the evidence supporting its evolution into the CRISPR system.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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