Can CRISPR-Cas9 gene drives curb malaria?

Luke Alphey, Nature Biotechnology (2016) 34:149-150

Gene drives use selfish genes that spread through a population regardless of its ability to confer individual fitness.  Multiple researchers have proposed using gene drives to control the spread of vector-borne diseases, such as malaria.  Carried by certain species of mosquitos, malaria is one of the most dangerous human pathogens, gene drives could control or eliminate malaria by modifying mosquitoes to be resistant to malaria or by elimination of mosquito fertility.  This opinion article highlights how CRISPR/Cas9 gene drives would work in theory as well as a discussion on the technological and ethical problems facing gene drives.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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