Hoyland-Kroghsbo, N.M. et. al. (2016) PNAS https://www.ncbi.nlm.nih.gov/pubmed/27849583
The CRISPR/Cas system is a bacterial adaptive immune system for protection against bacteriophages. While much is known about how the CRISPR/Cas system targets and cleaves invading DNA, little is understood about its activation and regulation. In a new PNAS report, Hoyland-Kroghsbo et. al. demonstrated that CRISPR/Cas regulation, including acquisition of phage DNA at the CRISPR locus, are modulated by quorum sensing, allowing bacteria to quickly respond to phage infection.