A single long range limb enhancer is responsible for normal limb development

Kvon, E. Z., et. al. (2016) Cell 167:633-642 https://www.ncbi.nlm.nih.gov/pubmed/27768887

Researches have now identified a single long range limb enhancer of Sonic hedgehog responsible for normal limb development in vertebrates.  By mutating the enhancer, Kvon et. al. were able to prevent normal limb development in mice and create a “Serpentized” mouse that lacks long limbs.  This transcription factor is conserved throughout vertebrates including fish but is not found in snakes.

Author: Advanced Analytical

Advanced Analytical Technologies, Inc. (AATI) simplifies complex genomics workflows to accelerate research and discovery in pharmaceuticals, life science, biofuels, biotechnology and healthcare.

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